A case series published online this week in the American Journal of Obstetrics & Gynecology has shown that 15% of pregnant women with COVID-19 have severe disease.

Erica M. Lokken, Ph.D., from the University of Washington in Seattle, and colleagues describe maternal disease and obstetrical outcomes associated with COVID-19 in a retrospective study of pregnant patients from six hospital systems between Jan. 21 and April 17, 2020.

Forty-six pregnant patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were identified. The researchers found that 93.5 percent of individuals with SARS-CoV-2 infection were symptomatic; 43.5 and 50.0 percent were in their second or third trimester, respectively. In a median of 24 days, symptoms resolved.

Seven of the women were hospitalized and one was admitted to the intensive care unit. Six cases (15 percent) were classified as severe COVID-19; nearly all patients with severe disease were overweight or obese before pregnancy, had asthma, or had other comorbidities.

During the study period, there were eight deliveries, including one preterm birth at 33 weeks to improve pulmonary status in a woman with Class III obesity. There was one stillbirth of unknown etiology.

“Taken together,” the authors conclude, “pregnant women should be considered a high risk population for severe COVID-19 disease, particularly for women in the second and third trimesters that began pregnancy overweight or obese.”

SOURCE: https://www.practiceupdate.com/c/100950/2/20/?elsca1=emc_enews_daily-digest&elsca2=email&elsca3=practiceupdate_rm&elsca4=respiratorymedicine&elsca5=newsletter&rid=NTU2MjE4MTIzNzES1&lid=10332481

REFERENCE: Lokken et al: Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State; https://www.ajog.org/article/S0002-9378(20)30558-5/fulltext