Further to an exclusive Med Brief Africa interview on “Protecting pregnant women against COVID-19” (12 March), a study report has since shown that the virus was not transmitted to infants born to women with the virus in four specific cases.

Four infants born to pregnant women who tested positive for coronavirus 2019 (COVID-19) were healthy at birth and had no serious clinical symptoms, according to a case series study published online this week in Frontiers in Pediatrics.

Yan Chen, M.D., from Huazhong University of Science and Technology in China, and colleagues report on the clinical course of four live born infants born to pregnant women who tested positive for COVID-19 infection in Wuhan, China.

The researchers found that none of the three infants who were diagnostically tested were positive for the virus. None developed serious clinical symptoms, including fever, cough, diarrhoea, or abnormal radiologic or hematologic evidence. At hospital discharge, all four infants were still alive.

Two infants had rashes of unknown aetiology at birth, and facial ulcerations were observed in one infant. Tachypnea was noted in one infant, who was supported with three days of non-invasive mechanical ventilation. One infant had rashes at birth, but there was no parental consent for a diagnostic test.

“It’s worth noting that both [infant cases 2 and 3] showed transient skin rash after birth,” the authors wrote.

“Whether this was attributable to the maternal inflammatory toxin effect [needs] further study.”

SOURCE: https://www.practiceupdate.com/c/97915/2/6/?elsca1=emc_enews_daily-digest&elsca2=email&elsca3=practiceupdate_primary&elsca4=primary-care&elsca5=newsletter&rid=NTU2MjE4MTIzNzES1&lid=10332481

REFERENCE: Chen et al: Infants Born to Mothers With a New Coronavirus (COVID-19); https://www.frontiersin.org/articles/10.3389/fped.2020.00104/full